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8.52133

Sigma-Aldrich

Fmoc-Gln(Trt)-OPfp

Novabiochem®

Synonym(s):

Fmoc-Gln(Trt)-OPfp, N-α-Fmoc-N-γ-trityl-L-glutamine pentafluorophenyl ester

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About This Item

Empirical Formula (Hill Notation):
C45H33F5N2O5
CAS Number:
Molecular Weight:
776.75
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.22

Quality Level

product line

Novabiochem®

Assay

≥98.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amide

storage temp.

15-25°C

InChI

1S/C45H33F5N2O5/c46-37-38(47)40(49)42(41(50)39(37)48)57-43(54)35(51-44(55)56-26-34-32-22-12-10-20-30(32)31-21-11-13-23-33(31)34)24-25-36(53)52-45(27-14-4-1-5-15-27,28-16-6-2-7-17-28)29-18-8-3-9-19-29/h1-23,34-35H,24-26H2,(H,51,55)(H,52,53)/t35-/m0/s1

InChI key

OLYKAAWLZTVISS-DHUJRADRSA-N

General description

Pre-formed pentafluorophenyl ester for coupling of glutamine amino-acid residues by Fmoc SPPS. Use enables bromophenol blue monitoring of amide bond formation.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS


Literature references

[1] P. Sieber, et al. (1991) Tetrahedron Lett., 32, 739.

Linkage

Replaces: 04-12-1539

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in dioxan): -8.0 - -5.0 °
Purity (TLC (0004)): <2% DCU
Assay (HPLC, area%): ≥ 98.0% (a/a)
Solubility (0.5 mmole in 3 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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