8.21092

Tetrahydrofurfuryl alcohol polyethylene glycol ether

for synthesis

• Synonym(s): Tetrahydrofurfuryl alcohol polyethylene glycol ether, Glycofurol
• CAS Number: 31692-85-0
• UNSPSC Code: 12352104
• NACRES: NA.22
• MDL number: MFCD00801146

Properties

• Quality Segment: 200
• form: liquid
• bp: 176 °C/40 hPa
• density: 1.08 g/cm³ at 20 °C
• storage temp.: 2-30°C
• SMILES string: O1C(CCC1)COCCO
• InChI: 1S/C7H14O3/c8-3-5-9-6-7-2-1-4-10-7/h7-8H,1-6H2
• InChI key: CTPDSKVQLSDPLC-UHFFFAOYSA-N

Description

Application

• Biodegradable microparticle production: A novel green process employing CO2 medium was developed for the production of biodegradable microparticles encapsulating TGF-beta1, utilizing tetrahydrofurfuryl alcohol polyethylene glycol ether, enhancing the sustained release properties of the therapeutic proteins (Swed et al., 2015).


• Nanocarrier devices for targeted drug delivery: Tetrahydrofurfuryl alcohol polyethylene glycol ether was utilized in the formulation of photosensitizer-loaded nanocarrier devices, bridging laboratory and large-scale production, and demonstrating potential in targeted drug delivery systems (Beyer et al., 2015).


• Cardiac tissue-engineering: In cardiac tissue engineering, tetrahydrofurfuryl alcohol polyethylene glycol ether was incorporated into a thermosensitive hydrogel for releasing growth factors from pharmacologically active microcarriers, presenting a biomimetic 3D scaffold that supports cardiac cell growth (Karam et al., 2014).


• Enhanced pharmacokinetics in drug delivery: A self-microemulsifying drug delivery system incorporating tetrahydrofurfuryl alcohol polyethylene glycol ether demonstrated improved pharmacokinetics for tacrolimus, suggesting its efficacy in bioavailability enhancement (von Suesskind-Schwendi et al., 2013).

Analysis Note

Density (d 20 °C/ 4 °C): 1.080 - 1.090
Identity (IR): passes test

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: 275.0 °F - closed cup
• flash_point_c: 135 °C - closed cup