565000

Serine Protease Inhibitor Cocktail Set I - Calbiochem

• NACRES: NA.28
• UNSPSC Code: 12352209

Properties

• form: solid
• manufacturer/tradename: (Calbiochem)
• storage condition: dry at room temperature (Tightly closed)
• technique(s): inhibition assay: suitable
• input: general use sample(s)
• solubility: water: soluble
• suitability: suitable for activity/function inhibition
• NCBI accession no.: NP_000615.3NP_000615.3NP_000615.3NP_000615.3NP_000615.3NP_000615.3
• UniProt accession no.: P05154
• application(s): life science and biopharma
• shipped in: dry ice
• storage temp.: -10 to -25°C
• Gene Information: human ... SERPINA(5104)

Description

General description

The Serine Protease Inhibitor Cocktail Set I, called Serpins, is a mixture of highly specific inhibitor protein that provides a broad range of serine protease inhibition. This product specifically inhibits serine proteases using inhibitors such as 4-benzenesulfonyl fluoride hydrochloride (AEBSF), and Aprotinin.

Application

The Serine Protease Inhibitor Cocktail Set I – Calbiochem may be used:

• to protect proteins from serine protease degradation during cell or tissue lysis to preserve sample integrity.
• to maintain protein stability and native state in downstream proteomic analyses such as Western blotting, immunoprecipitation, and mass spectrometry.
• to support accurate protein quantification and characterization in studies involving biomarker discovery and post-translational modifications.

Biochem/physiol Actions

Serine proteases are enzymes involved in processes like coagulation, fibrinolysis, inflammation, apoptosis, and tissue homeostasis. It acts through complimentary and overlapping inhibitory mechanisms. Serpins like 4-Benzenesulfonyl fluoride hydrochloride (AEBSF) inhibit serine proteases by reacting rapidly with the enzyme′s catalytic serine residue. This reaction forms a stable acyl-enzyme complex that prevents protease from breaking down proteins to stop its activity.

Safety Information

• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1A
• wgk: WGK 3