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RNA Polymerase III Inhibitor

Name: RNA Polymerase III Inhibitor
Brand: MM
Price: 10300 CZK

RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC₅₀= 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively).

Synonym(s):

RNA Polymerase III Inhibitor, ML-60218, N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide

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Size/SKU	Availability	Price
10 mg	Check Cart for Availability	10 300,00 CZK

About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₅Cl₂N₃O₂S₂

CAS Number:

577784-91-9

Molecular Weight:

452.38

MDL number:

MFCD00112663

UNSPSC Code:

12352200

NACRES:

NA.54

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

10 300,00 CZK

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Properties

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

input

general use sample(s)

solubility

DMSO: 15 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(Nc2[n](nc(c2)c3[s]c4c(c3C)cc(cc4)Cl)C)c1c(cccc1)Cl

InChI

1S/C19H15Cl2N3O2S2/c1-11-13-9-12(20)7-8-16(13)27-19(11)15-10-18(24(2)22-15)23-28(25,26)17-6-4-3-5-14(17)21/h3-10,23H,1-2H3

InChI key

BVBDTTLISMIOJY-UHFFFAOYSA-N

Description

General description

A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
activity against RNA Polymerase III

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 27 and 32 µM for Human and S. cerevisiae RNA Pol III

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Slight warming may be necessary to achieve complete solubilization.

Other Notes

Wu, L., et al. 2003. Euk. Cell2, 256.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

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This Item	361555	420143
Sigma-Aldrich 557403 RNA Polymerase III Inhibitor	Sigma-Aldrich 361555 GSK-3 Inhibitor XIII	Sigma-Aldrich 420143 JNK3 Inhibitor XII, SR-3576
description RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC₅₀= 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively).	description The GSK-3 Inhibitor XIII, also referenced under CAS 404828-08-6, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description The JNK3 Inhibitor XII, SR-3576, also referenced under CAS 1164153-22-3, controls the biological activity of JNK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
form solid	form solid	form solid
assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition OK to freeze, protect from light	storage condition OK to freeze, protect from light	storage condition OK to freeze, protect from light

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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