459618

Okadaic Acid potassium salt

≥95% (HPLC), solid, protein phosphatase 2A and protein phosphatase 1 inhibitor, Calbiochem^®

• Synonym(s): Okadaic Acid, Potassium Salt
• Empirical Formula (Hill Notation): C₄₄H₆₇O₁₃ · K
• CAS Number: 155751-72-7
• Molecular Weight: 843.09
• UNSPSC Code: 12352106
• NACRES: NA.77
• MDL number: MFCD00214356
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Properties

• Product Name: Okadaic Acid, Potassium Salt, Water-soluble analog of Okadaic Acid. Inhibits protein phosphatases 1 and 2A.
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: water: 1 mg/mL, DMSO: 20 mg/mL, ethanol: 20 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [K+].[O-]C(=O)C(O)(CC1OC2(OC(CC(=C2)C)C(C)C=CC3OC4(OC5C(OC(C(=C)C5O)C(O)CC(C6OC7(OCCCC7)CCC6C)C)CC4)CC3)C(CC1)O)C
• InChI: 1S/C44H68O13.K/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42;/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49);/q;+1/p-1
• InChI key: UXRQUXBFVICHQJ-UHFFFAOYSA-M

Description

General description

Water-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A.

Biochem/physiol Actions

Cell permeable: no

Primary Target
PP1, PP2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 10-15 nM, 0.1 nM, against protein phosphatase 1 and protein phosphatase 2A, respectively

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Gjertsen, B.T., et al. 1994. J. Cell Sci.107, 3363.
Kiguchi, K., et al. 1994. Cell Growth Differ.5, 995.
Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun.197, 916.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun.189, 950.
Kreienbuhl, P., et al. 1992. Blood80, 2911.
Nomura, M., et al. 1992. Biochemistry31, 11915.
Song, Q., et al. 1992. J. Cell Physiol.153, 550.
Tada, Y., et al. 1992. Immunopharmacol.24, 17.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 + H311 + H331,H315
• pcodes: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable