437720

Lipoxin A₄

≥95% (HPLC), NK cell activity inhibitor, liquid

• Synonym(s): Lipoxin A₄, LXA₄, 5(S),6(R),15(S)-Trihydroxyeicosa-7- trans-9- trans-11- cis-13- trans-tetraenoic Acid, LXA₄, 5(S),6(R),15(S)-Trihydroxyeicosa-7-trans-9-trans-11-cis-13-trans-tetraenoic Acid
• Empirical Formula (Hill Notation): C₂₀H₃₂O₅
• CAS Number: 89663-86-5
• Molecular Weight: 352.47
• UNSPSC Code: 12352211
• NACRES: NA.77
• MDL number: MFCD00065845
• Assay: ≥95% (HPLC)
• Form: liquid
• Storage condition: OK to freeze

Properties

• Product Name: Lipoxin A₄, Lipoxin A₄, CAS 89663-86-5, is a potent inhibitor of cytotoxic activity of human natural killer cells. Shown to be as potent as LTB4 in stimulating human neutrophils to generate superoxides.
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• solubility: ethanol: soluble
• shipped in: wet ice
• storage temp.: −70°C
• SMILES string: O[C@H]([C@H](O)\C=C\C=C\C=C/C=C/[C@@H](O)CCCCC)CCCC(=O)O
• InChI: 1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
• InChI key: IXAQOQZEOGMIQS-SSQFXEBMSA-N

Description

General description

Caution! Product contains volatile liquid. Keep product cold at all times.

Potent inhibitor of cytotoxic activity of human natural killer cells; shown to be as potent as LTB₄ in stimulating human neutrophils to generate superoxides. Involved in contractile responses and acts as a potent activator of human protein kinase C. Stimulates rapid lipid remodeling and pertussis-sensitive release of arachidonic acid in polymorphonuclear leukocytes. Stimulates MAP kinases via activation of G protein-coupled receptors.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Potent inhibitor of cytotoxic activity of human natural killer cells

Product does not compete with ATP.

Reversible: no

Physical form

In Ethanol.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

McMahon, B., et al. 2000. J. Biol. Chem. 275, 27566.
Soyombo, O., et al. 1994. Allergy 49, 230.
Flore, S., et al. 1992. J. Biol. Chem.267, 16168.
Badr, K.F., et al. 1989. Proc. Natl. Acad. Sci. USA86, 3438.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Flammable (J)

Safety Information

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H225,H319
• pcodes: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Storage Class: 3 - Flammable liquids
• wgk: WGK 2