368055

Granzyme B Inhibitor II

The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(s): Granzyme B Inhibitor II, Caspase-8 Inhibitor I, Ac-IETD-CHO
• Empirical Formula (Hill Notation): C₂₁H₃₄N₄O₁₀
• CAS Number: 1258003-96-1
• Molecular Weight: 502.52
• MDL number: MFCD01318858
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: lyophilized solid
• Storage condition: OK to freeze

Properties

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: N([C@@H]([C@@H](O)C)C(=O)N[C@@H](CC(=O)O)C=O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)[C@H](CC)C)CCC(=O)O
• InChI key: AXTKTZHLZLOIIO-WBOIFEBMSA-N

Description

General description

A potent, reversible inhibitor of granzyme B and caspase-8 (K_i = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).

Potent, reversible granzyme B and caspase-8 inhibitor.

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: yes

Target K_i: 1 nM against caspase-8

Other Notes

Ac-Ile-Glu-Thr-Asp-CHO

Gao, C.F., et al. 2001. Exp. Cell. Res.265, 145.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem.273, 32608.
Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable