341209

EUK-8

A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities.

• Synonym(s): EUK-8
• Empirical Formula (Hill Notation): C₁₆H₁₄ClMnN₂O₂
• CAS Number: 53177-12-1
• Molecular Weight: 356.69
• MDL number: MFCD00933789
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥90% (elemental analysis)
• Form: solid
• Storage condition: OK to freeze, protect from light

Properties

• Quality Segment: 100
• assay: ≥90% (elemental analysis)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: dark brown
• solubility: DMSO: 20 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [Mn+3].[Cl-].N(=C\c2c(cccc2)[O-])/CC\N=C\c1c(cccc1)[O-]
• InChI: 1S/C16H16N2O2.ClH.Mn/c19-15-7-3-1-5-13(15)11-17-9-10-18-12-14-6-2-4-8-16(14)20;;/h1-8,11-12,19-20H,9-10H2;1H;/q;;+3/p-3/b17-11+,18-12+;;
• InChI key: HBQGFROGWOHBAG-SNTCFBDDSA-K

Description

General description

A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents β-amyloid peptide (Aβ)-induced free radical formation and lipid peroxidation. Imparts protection against Aβ₄₀ and Aβ₄₂ toxicity in hippocampal cultures.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.

Other Notes

Colparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol.130, 359.
Brandier, C., et al. 1997. J. Vasc. Res. 34, 49.
Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247.
Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312.
Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331.
Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.

Legal Information

Not available for sale in Africa, Australia, Great Britain, Europe, Latvia, New Zealand, and the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 2