324895

eIF-2α Inhibitor, Salubrinal

eIF-2α Inhibitor, Salubrinal, CAS 304475-63-6, is a cell-permeable, selective inhibitor of the phosphatase complexes that dephosphorylate eIF-2α. Protects cells against ER stress-induced apoptosis.

• Synonym(s): eIF-2α Inhibitor, Salubrinal, Sal
• Empirical Formula (Hill Notation): C₂₁H₁₇Cl₃N₄OS
• CAS Number: 304475-63-6
• Molecular Weight: 479.81
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥90% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Properties

• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: beige
• solubility: DMSO: 10 mg/mL
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC₅₀ ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC₅₀ ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
elF-2α

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 3 µM preventing HSV replication both in Vero cells.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Boyce, M., et al. 2005. Science307, 935.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable