239785

Cyclophosphamide Monohydrate

≥98% (HPLC), solid, anti-neoplastic agent, Calbiochem^®

• Synonym(s): Cyclophosphamide Monohydrate, N,N- bis(2-Chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide Monohydrate, CPA, N,N-bis(2-Chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide Monohydrate, CPA
• Empirical Formula (Hill Notation): C₇H₁₅Cl₂N₂O₂P · xH₂O
• CAS Number: 6055-19-2
• Molecular Weight: 261.09 (anhydrous basis)
• UNSPSC Code: 51112507
• NACRES: NA.77
• MDL number: MFCD00149395
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Properties

• Product Name: Cyclophosphamide Monohydrate, A widely used anti-neoplastic agent that also displays immunosuppressant properties.
• Quality Segment: 100
• description: Merck USA index - 14, 747
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: water: 30 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [P]1(=O)(NCCCO1)N(CCCl)CCCl.O
• InChI: 1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
• InChI key: PWOQRKCAHTVFLB-UHFFFAOYSA-N

Description

General description

A widely used anti-neoplastic agent that also displays immunosuppressant properties. Induces apoptotic cell death in rat thymus through the Fas/Fas ligand pathway.

A widely used antineoplastic agent that also displays immuno-suppressant activity. Induces apoptotic cell death in rat thymus throught Fas/Fas ligand pathway.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Fas/Fas ligand pathway

Product does not compete with ATP.

Reversible: no

Preparation Note

Solutions should be prepared fresh on the day of use.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Wang, G.J., and Cai, L. 1999. Mutat. Res.427, 125.
Lee, J.H., et al. 1997. Korean J. Med. Sci. 12, 185.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H340,H350,H360FD
• pcodes: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 1A
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3