236015

COX-2 Inhibitor V, FK3311

The COX-2 Inhibitor V, FK3311, also referenced under CAS 116686-15-8, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• Synonym(s): COX-2 Inhibitor V, FK3311, 4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide
• Empirical Formula (Hill Notation): C₁₅H₁₃F₂NO₄S
• CAS Number: 116686-15-8
• Molecular Weight: 341.33
• MDL number: MFCD00876455
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: ethanol: 15 mg/mL, DMSO: 30 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: Fc1c(ccc(c1)F)Oc2c(ccc(c2)C(=O)C)N[S](=O)(=O)C
• InChI: 1S/C15H13F2NO4S/c1-9(19)10-3-5-13(18-23(2,20)21)15(7-10)22-14-6-4-11(16)8-12(14)17/h3-8,18H,1-2H3
• InChI key: DIIYLGZNZGPXRR-UHFFFAOYSA-N

Description

General description

A cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC₅₀ = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC₅₀ = 160 µM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung in vivo.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Otani, Y., et al. 2007. J. Invest. Surg.20, 175.
Sunose, Y., et al. 2001. Transplant Proc.33, 862.
Grossman, C.J., et al. 1995. Inflamm. Res.44, 253.
Nakamura, K., et al. 1993. Chem. Pharm. Bull.41, 2050.
Tsuji, K., et al. 1992. Chem. Pharm. Bull.40, 2399.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable