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231085

Cilostamide

A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 70 nM).

Synonym(s):

Cilostamide, N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide, OPC 3689

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Size/SKUAvailabilityPrice
10 mg

Available to ship TODAYfromAreál Kühne+Nagel spol. s r.o.

CZK 8,290.00

About This Item

Empirical Formula (Hill Notation):
C20H26N2O3
CAS Number:
68550-75-4
Molecular Weight:
342.43
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00673958
Assay:
≥98% (TLC)
Form:
solid
Storage condition:
OK to freeze

CZK 8,290.00

Available to ship TODAYDetails

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Quality Segment

100

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[nH]1c2c(cc[c]1=O)cc(cc2)OCCCC(=O)N(C3CCCCC3)C

InChI

1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)

InChI key

UIAYVIIHMORPSJ-UHFFFAOYSA-N

General description

A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 70 nM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PDE 3
Product does not compete with ATP.
Reversible: no
Target IC50: 70 nM against PDE III

Preparation Note

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.

Other Notes

Verghese, M.W., et al. 1995. J. Pharmacol. Exp. Ther. 272, 1313.
Christensen, S.B., and Trophy, T.J. 1994. Ann. Rep. Med. Chem. 29, 185.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item
454202C7971324813
Cilostamide A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 70 nM).

Sigma-Aldrich

231085

Cilostamide

8-Methoxymethyl-3-isobutyl-1-methylxanthine A cell-permeable selective inhibitor of Ca2+-calmodulin-dependent phosphodiesterase (PDE I; IC50 = 4 µM).

Sigma-Aldrich

454202

8-Methoxymethyl-3-isobutyl-1-methylxanthine

Cilostamide phosphodiesterase inhibitor

Sigma-Aldrich

C7971

Cilostamide

Soluble Epoxide Hydrolase Inhibitor, NCND The Soluble Epoxide Hydrolase Inhibitor, NCND, also referenced under CAS 402939-18-8, controls the biological activity of Soluble Epoxide Hydrolase.

Sigma-Aldrich

324813

Soluble Epoxide Hydrolase Inhibitor, NCND

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥97% (HPLC)

assay

≥95% (TLC)

form

solid

form

solid

form

powder

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

10-30°C

storage temp.

-

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL

solubility

ethanol: 2 mg/mL, DMSO: 5 mg/mL

solubility

DMSO: 20 mg/mL, clear, colorless to faintly yellow

solubility

dichloromethane: 1 mg/mL

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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