220202

CHAPSO

Unique detergent with high CMC that solubilizes membrane-bound proteins in their native state.

• Synonym(s): CHAPSO, 3-[(3-Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate
• Empirical Formula (Hill Notation): C₃₂H₅₈N₂O₈S
• CAS Number: 82473-24-3
• Molecular Weight: 630.88
• UNSPSC Code: 12161902
• NACRES: NA.25
• MDL number: MFCD00081079

Properties

• Quality Segment: 100
• assay: >98% (TLC)
• form: solid
• mol wt: micellar wt 9960
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• aggregation number: 11
• color: white
• CMC: 8 mM
• solubility: water: soluble
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [S](=O)(=O)([O-])CC(O)C[N+](CCCNC(=O)CC[C@H]([C@@H]1[C@@]2([C@H]([C@H]3[C@@H]([C@@]4([C@H](C[C@H]3O)C[C@@H](CC4)O)C)C[C@@H]2O)CC1)C)C)(C)C
• InChI: 1S/C32H58N2O8S/c1-20(7-10-29(39)33-13-6-14-34(4,5)18-23(36)19-43(40,41)42)24-8-9-25-30-26(17-28(38)32(24,25)3)31(2)12-11-22(35)15-21(31)16-27(30)37/h20-28,30,35-38H,6-19H2,1-5H3,(H-,33,39,40,41,42)/t20-,21+,22-,23?,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1
• InChI key: GUQQBLRVXOUDTN-XOHPMCGNSA-N

Description

General description

Unique detergent with high CMC that solubilizes membrane-bound proteins in their native state (aggregation number: 11; CMC: 8 mM; micellar weight: 9960). Capable of solubilizing the opiate receptor to a state exhibiting reversible binding of opiates. Has a higher solubility than CHAPS because of its more polar head group.

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 days at 4°C.

Other Notes

Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA77, 4623.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable