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219399

Cathepsin D Substrate I

Useful as a substrate for the determination of cathepsin D activity.

Synonym(s):

Cathepsin D Substrate I, Bz-RGFFP-4-MeOβNA, HCl

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10 mg

Available to ship TODAYfromAreál Kühne+Nagel spol. s r.o.

2 660,00 CZK

About This Item

Empirical Formula (Hill Notation):
C49H55N9O7 · xHCl
Molecular Weight:
882.02 (free base basis)
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Storage condition:
OK to freeze, desiccated, protect from light

2 660,00 CZK

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Quality Segment

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated, protect from light

color

white

solubility

DMSO: 5 mg/mL

fluorescence

λex ~345 nm, λem ~425 nm

shipped in

ambient

storage temp.

−20°C

General description

A useful substrate for colorimetric or fluorometric assay of cathepsin D activity. Cathepsin D hydrolyzes the Phe-Phe bond. Dipeptidyl aminopeptidase II is required to free the 4-methoxy-β-naphthylamine (4MβNA). Excitation max: ~345 nm; emission max: ~425 nm.
Useful as a substrate for the determination of cathepsin D activity. Suitable for either colorimetric or fluorometric assay. Cathepsin D hydrolyzes the Phe-Phe bond. Requires dipeptidyl aminopeptidase II to free 4-methoxy-β-naphthylamine (4MeOβNA).

Biochem/physiol Actions

Cell permeable: no
Primary Target
Substrate for the determination of cathepsin D activity
Product does not compete with ATP.
Reversible: no

Other Notes

Bz-Arg-Gly-Phe-Phe-Pro-4MeOβNA, HCl
Takahashi, T., and Tang, J. 1981. Methods Enzymol.80, 565.
Smith, R.E., and Van Frank, R.M. 1975. in Lysosomes in Biology and Pathology4 (Dingle, J.T., and Dean, R.T., eds.) p. 193, American Elsevier, Holland.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Cathepsin D Substrate I Useful as a substrate for the determination of cathepsin D activity.

Sigma-Aldrich

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Cathepsin D Substrate I

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Sigma-Aldrich

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Cathepsin B Substrate III, Fluorogenic

Cathepsin K Substrate II, Fluorogenic An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (kcat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.

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Cathepsin K Substrate II, Fluorogenic

Caspase-9 Substrate I, Fluorogenic A fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6).

Sigma-Aldrich

218765

Caspase-9 Substrate I, Fluorogenic

description

Useful as a substrate for the determination of cathepsin D activity.

description

Sensitive fluorogenic substrate for the quantitative determination of cathepsin B activity.

description

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (kcat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.

description

A fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6).

form

lyophilized solid

form

lyophilized solid

form

solid

form

solid

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 5 mg/mL

solubility

DMSO: 5 mg/mL, water: soluble

solubility

DMSO: 5 mg/mL

solubility

DMSO: 5 mg/mL

Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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