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215901

Carbonic Anhydrase IX/XII Inhibitor II, U-104

The Carbonic Anhydrase IX/XII Inhibitr II, U-104 controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

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Synonym(s):

Carbonic Anhydrase IX/XII Inhibitor II, U-104, CAIX Inhibitor II

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5 mg

Estimated to ship TODAYfromAreál Kühne+Nagel spol. s r.o.

2 690,00 CZK

About This Item

Empirical Formula (Hill Notation):
C13H12FN3O3S
Molecular Weight:
309.32
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00159265
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light

2 690,00 CZK

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Quality Segment

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)NC(=O)Nc2ccc(cc2)[S](=O)(=O)N

InChI key

YJQZNWPYLCNRLP-UHFFFAOYSA-N

General description

A cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 5080 nM and 9640 nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38 mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.

Packaging

Packaged under inert gas

Other Notes

Lock, F.E., et al. 2012. Oncogenein press.
Pacchiano, F., et al. 2011. J Med Chem.54, 1896.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

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This Item
215900238811382110
Carbonic Anhydrase IX/XII Inhibitor II, U-104 The Carbonic Anhydrase IX/XII Inhibitr II, U-104 controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

215901

Carbonic Anhydrase IX/XII Inhibitor II, U-104

Carbonic Anhydrase IX/XII Inhibitor The Carbonic Anhydrase IX/XII Inhibitor controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

215900

Carbonic Anhydrase IX/XII Inhibitor

Cdk9 Inhibitor II The Cdk9 Inhibitor II, also referenced under CAS 140651-18-9, controls the biological activity of Cdk9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

238811

Cdk9 Inhibitor II

Histone Acetyltransferase Inhibitor II The Histone Acetyltransferase Inhibitor II, also referenced under CAS 932749-62-7, controls the biological activity of Histone Acetyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

Sigma-Aldrich

382110

Histone Acetyltransferase Inhibitor II

description

The Carbonic Anhydrase IX/XII Inhibitr II, U-104 controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

description

The Carbonic Anhydrase IX/XII Inhibitor controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

description

The Cdk9 Inhibitor II, also referenced under CAS 140651-18-9, controls the biological activity of Cdk9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

description

The Histone Acetyltransferase Inhibitor II, also referenced under CAS 932749-62-7, controls the biological activity of Histone Acetyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (HPLC)

form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 50 mg/mL

solubility

DMSO: 50 mg/mL

solubility

ethanol: 5 mg/mL, DMSO: 10 mg/mL

solubility

ethanol: 10 mg/mL, DMSO: 25 mg/mL

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
4059326
3930302
4044220

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