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178281

p-APMSF hydrochloride

≥97% (HPLC), irreversible trypsin-like serine proteases inhibitor, solid

Synonym(s):

p-APMSF, Hydrochloride, p-Amidinophenylmethylsulfonylfluoride, HCl

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
4 300,00 CZK

About This Item

CAS Number:
74938-88-8
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00078902
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated

4 300,00 CZK

Please contact Customer Service for Availability
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Product Name

p-APMSF, Hydrochloride, Alternative to DFP and PMSF.

Quality Segment

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

color

white

solubility

water: 25 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

F[S](=O)(=O)Cc1ccc(cc1)\C(=N\[H])\N.Cl

InChI

1S/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H

InChI key

KHLLRHIUKOJXLL-UHFFFAOYSA-N

General description

Alternative to DFP and PMSF. An irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentration. Acts on C1r, C1s, Factor Xa, and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF.
An alternative to DFP and PMSF. Specific irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentrations. Acts on C1r, C1s, Factor Xa and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF. Stability is pH dependent: t½ = 20 min at pH 6.0; 6 min at pH 7.0; 1 millisecond at pH 8.0.

Biochem/physiol Actions

Cell permeable: no
Primary Target
trypsin-like serine proteases
Product does not compete with ATP.
Reversible: no

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Cole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
Laura, R., et al. 1980. Biochemistry19, 4859.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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p-APMSF, Hydrochloride Alternative to DFP and PMSF.

Sigma-Aldrich

178281

p-APMSF, Hydrochloride

Bisindolylmaleimide I, Hydrochloride An enhanced water-soluble form of Bisindolylmaleimide I.

Sigma-Aldrich

203291

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Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide Sensitive chromogenic substrate for human leukocyte cathepsin G that is not reactive with elastase.

Sigma-Aldrich

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p-Aminophenylmercuric Acetate An organomercurial agent used for the activation of latent MMPs in vitro. Acts by facilitating the loss of the enzyme propeptide domain through an autolytic cleavage known as the cysteine switch.

Sigma-Aldrich

164610

p-Aminophenylmercuric Acetate

description

Alternative to DFP and PMSF.

description

An enhanced water-soluble form of Bisindolylmaleimide I.

description

Sensitive chromogenic substrate for human leukocyte cathepsin G that is not reactive with elastase.

description

An organomercurial agent used for the activation of latent MMPs in vitro. Acts by facilitating the loss of the enzyme propeptide domain through an autolytic cleavage known as the cysteine switch.

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥90% (HPLC)

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

10-30°C

storage condition

OK to freeze, desiccated

storage condition

OK to freeze

storage condition

OK to freeze, desiccated

storage condition

OK to freeze

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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