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GCN2, active

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Size/SKU	Availability	Price
10 μg	Estimated to ship onJune 03, 2026fromAreál Kühne+Nagel spol. s r.o.	CZK 13,600.00
250 μg	Estimated to ship onJune 05, 2026fromAreál Kühne+Nagel spol. s r.o.	CZK 86,800.00

About This Item

UNSPSC Code:

12352200

NACRES:

NA.32

eCl@ss:

32160405

Biological source:

human

CZK 13,600.00

Estimated to ship onJune 03, 2026Details

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Properties

biological source

human

Quality Segment

100

mol wt

M_w 215 kDa

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

Description

General description

GCN2 (EIF2AK4) belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1) to downregulate protein synthesis in response to varied cellular stresses.

Product Source: N-terminal GST-tagged, recombinant, human GCN2 full length, expressed by baculovirus in Sf21 insect cells. The recombinant protein contains the amino acid substitution E556G with reference to GenPept NP_001013725. E556G is reported in GenPept CAH10626.

Biochem/physiol Actions

Target Sub-Family: STE

Packaging

Also available in 250μg size as catalog # 14-934M and in bulk as catalog # 14-934-K.

Physical form

Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.

Purified using glutathione sepharose.

Preparation Note

6 months at -70°C

Analysis Note

Routinely evaluated by phosphorylation of peptide RSRSRSRSRSRSRSR

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SRP5218	MABN450	HPA026776
Sigma-Aldrich 14-934-M GCN2, active	Sigma-Aldrich SRP5218 EIF2AK4 (192-1024), active, GST tagged human	Sigma-Aldrich MABN450 Anti-GCM2 Antibody, clone 8A10.1	Sigma-Aldrich HPA026776 Anti-GCNT2 antibody produced in rabbit
technique(s) activity assay: suitable (kinase)	technique(s) -	technique(s) western blot: suitable	technique(s) immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:50-1:200
biological source human	biological source -	biological source mouse	biological source rabbit
Gene Information human ... EIF2AK4(440275)	Gene Information human ... EIF2AK4(440275)	Gene Information human ... GCM2(9247)	Gene Information human ... GCNT2(2651)
UniProt accession no. Q9P2K8	UniProt accession no. -	UniProt accession no. O75603	UniProt accession no. Q8N0V5
mol wt M_w 215 kDa	mol wt ~132 kDa	mol wt -	mol wt -
NCBI accession no. NP_001013725	NCBI accession no. NM_001013703	NCBI accession no. NP_004743	NCBI accession no. -

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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