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Key Documents

09-078

Sigma-Aldrich

Anti-EHMT1/GLP1 Antibody

Upstate®, from rabbit

Synonym(s):

G9a like protein, H3-K9-HMTase, Histone H3-K9 methyltransferase, Histone-lysine N-methyltransferase, H3 lysine-9 specific, EC 2.1.1.43, euchromatic histone methyltransferase 1, euchromatic histone-lysine N-methyltransferase 1, Eu-HMTase1, FLJ12879 1, FP1

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25 μG
$182.00

$182.00

Estimated to ship onMay 26, 2025

A recombinant, preservative-free antibody is available for your target. Try ZMS1029
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25 μG
$182.00

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

$182.00

Estimated to ship onMay 26, 2025

A recombinant, preservative-free antibody is available for your target. Try ZMS1029
Request a Bulk Order

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

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species reactivity

rabbit, monkey, sheep, mouse, Xenopus, human, pig, canine, rat

species reactivity

mouse, rat, human

species reactivity

human

species reactivity

mouse, rat, human

clone

C464.6, monoclonal

clone

polyclonal

clone

polyclonal

clone

C464.6, recombinant monoclonal

biological source

mouse

biological source

rabbit

biological source

rabbit

biological source

mouse

Gene Information

human ... ATP1A3(478)

Gene Information

human ... ATP1A2(477)
rat ... Atp1A2(24212)

Gene Information

rat ... Atp1A1(24211)

Gene Information

rat ... Atp1A1(24211)

UniProt accession no.

P05023

UniProt accession no.

P06686

UniProt accession no.

P06687

UniProt accession no.

P05023

General description

G9a-Like Protein 1 (GLP1), also known as Euchromatic histone lysine N-methyl-transferase 1 (EMHT1), is a histone methyltransferase that methylates Lys9 of histone H3. H3Lys9 methylation is a marker for epigenetic transcriptional repression. EMHT1/GLP1 is targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it contributes to silencing of Myc- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. EMHT1/GLP1 is phosphorylated upon DNA damage, probably by ATM or ATR. Defects in EHMT1 result in severe mental retardation, hypotonia, and epileptic seizures.

Specificity

Recognizes EMHT1/GLP1

Immunogen

Epitope: a.a. 40-59
KLH conjugated synthetic peptide (KHTQDSARVNPQDGTNTLTR(C) corresponding to a.a. 40-59 of human EMHT1/GLP1.

Application

Research Category
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology

Histones
Use Anti-EHMT1/GLP1 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect EHMT1/GLP1 also known as H3-K9-HMTase 5, Histone H3-K9 methyltransferase 5.

Quality

Routinely evaluated by immunoblot.

Target description

160 kda

Physical form

ImmunoAffinity Purified
Immunoaffinity purified rabbit IgG in PBS containing 0.1% sodium azide, 30% glycerol

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

    • Certificates of Analysis (COA)

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    Dan Levy et al.
    Nature immunology, 12(1), 29-36 (2010-12-07)
    Signaling via the methylation of lysine residues in proteins has been linked to diverse biological and disease processes, yet the catalytic activity and substrate specificity of many human protein lysine methyltransferases (PKMTs) are unknown. We screened over 40 candidate PKMTs
    Coralie Poulard et al.
    Cell death & disease, 9(10), 1038-1038 (2018-10-12)
    Synthetic glucocorticoids (GCs) are used to treat lymphoid cancers, but many patients develop resistance to treatment, especially to GC. By identifying genes that influence sensitivity to GC-induced cell death, we found that histone methyltransferases G9a and G9a-like protein (GLP), two
    Rui Wang et al.
    Journal of the American Chemical Society, 135(3), 1048-1056 (2012-12-19)
    Protein methyltransferases (PMTs) have emerged as important epigenetic regulators in myriad biological processes in both normal physiology and disease conditions. However, elucidating PMT-regulated epigenetic processes has been hampered by ambiguous knowledge about in vivo activities of individual PMTs particularly because
    Xiaopeng Lu et al.
    Nucleic acids research, 47(21), 10977-10993 (2019-10-16)
    The binding of p53-binding protein 1 (53BP1) to damaged chromatin is a critical event in non-homologous DNA end joining (NHEJ)-mediated DNA damage repair. Although several molecular pathways explaining how 53BP1 binds damaged chromatin have been described, the precise underlying mechanisms
    Coralie Poulard et al.
    EMBO reports, 18(8), 1442-1459 (2017-06-16)
    Like many transcription regulators, histone methyltransferases G9a and G9a-like protein (GLP) can act gene-specifically as coregulators, but mechanisms controlling this specificity are mostly unknown. We show that adjacent post-translational methylation and phosphorylation regulate binding of G9a and GLP to heterochromatin

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