07-1213

Anti-IP3 Receptor 1 Antibody

serum, from rabbit

• Synonym(s): IP3 receptor isoform 1, Type 1 InsP3 receptor, Type 1 inositol 1,4,5-trisphosphate receptor, inositol 1,4,5-triphosphate receptor, type 1, spinocerebellar ataxia 15, spinocerebellar ataxia 16
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC, WB
• Citations: 5

Properties

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: serum
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: mouse, human
• species reactivity (predicted by homology): canine, rat
• technique(s): immunohistochemistry: suitable (paraffin), western blot: suitable
• isotype: IgG
• UniProt accession no.: Q14643
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: dog ... Itpr1(476548) ; human ... ITPR1(3708) ; mouse ... Itpr1(16438) ; rat ... Itpr1(25262)

Description

General description

Approx. 300 kDa

IP3 Receptor 1 is an intracellular channel that when stimulated by inositol 1,4,5-triphosphate mediates the release of calcium from the endoplasmic reticulum. Defects within the gene ITPR1 cause a group of cerebellar disorders known as spinocerebellar ataxia type 15 (SCA15). This receptor is widely expressed in tissue.

Immunogen

Synthetic peptide from the N-terminal of human IP3 Receptor 1.

Application

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected IP3 Receptor 1 in mouse cerebellum tissue.

Research Category
Signaling

Research Sub Category
Lipid Signaling

This Anti-IP3 Receptor 1 Antibody is validated for use in IH(P), WB for the detection of IP3 Receptor 1.

Biochem/physiol Actions

The antibody reacts with the 300 kDa IP3 Receptor 1 protein.

Physical form

Rabbit serum. Liquid

Unpurified rabbit serum

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 1 year date of receipt. Avoid repeated freeze/thaw cycles.

Analysis Note

Control
C2C12 cell lysates

Evaluated by Western Blot in C2C12 cell lysates.
Western Blot Analysis: 1:500 dilution of this lot detected IP3 RECPT 1 on 10 ug of C2C12 lysates.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Replaces: AB9072

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable