03-32-1501

Z-Phe-Arg-7-amido-4-methylcoumarin, Hydrochloride

Substrate for fluorogenic assay of plasma and glandular kallikreins.

• Synonym(s): Z-Phe-Arg-7-amido-4-methylcoumarin, Hydrochloride
• Empirical Formula (Hill Notation): C₃₃H₃₆N₆O₆ · xHCl
• CAS Number: 70382-26-2
• Molecular Weight: 612.68 (free base basis)
• MDL number: MFCD00077030
• UNSPSC Code: 12352209
• NACRES: NA.83

Properties

• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: white to off-white
• solubility: 5% acetic acid: 1 mg/mL, DMSO: 1 mg/mL, water: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [Cl].N([C@@H](Cc4ccccc4)C(=O)N[C@@H](CCCNC(=N)N)C(=O)Nc2cc3c(cc2)C(=CC(=O)O3)C)C(=O)OCc1ccccc1
• InChI: 1S/C33H36N6O6.Cl/c1-21-17-29(40)45-28-19-24(14-15-25(21)28)37-30(41)26(13-8-16-36-32(34)35)38-31(42)27(18-22-9-4-2-5-10-22)39-33(43)44-20-23-11-6-3-7-12-23;/h2-7,9-12,14-15,17,19,26-27H,8,13,16,18,20H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,34,35,36);/t26-,27
• InChI key: QNRBQTLUAIXWTG-WMXJXTQLSA-N

Description

General description

Substrate for fluorogenic assay of plasma and glandular kallikreins. Also serves as a substrate for cathepsin B, cathepsin L, and papain.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Substrate for fluorogenic assay of plasma and glandular kallikreins

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Morita, T., et al. 1977. J. Biochem. 82, 1495.

Z-Phe-Arg-AMC, HCl

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Safety Information

• Storage Class: 11 - Combustible Solids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable