C-091

Clozapine-D₄ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₁₈D₄H₁₅ClN₄
• CAS Number: 204395-52-8
• Molecular Weight: 330.85
• EC Number: 200-659-6
• MDL number: MFCD12022180
• UNSPSC Code: 41116107
• PubChem Substance ID: 329774825
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: CN(CC1([2H])[2H])CC([2H])([2H])N1C2=NC(C=C(Cl)C=C3)=C3NC4=CC=CC=C24
• InChI: 1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3/i10D2,11D2
• InChI key: QZUDBNBUXVUHMW-MKQHWYKPSA-N

Description

General description

A stable-labled internal standard for quantitation of Clozapine levels in urine, serum, or plasma by LC/MS or GC/MS for clinical toxicology, forensic analysis, and urine drug testing applications. Clozapine, sold as Clozaril^® and FazaClo^® in the US, is an atypical antipsychotic drug used for treatment of schizophrenia.

Application

• Clozapine-D₄ internal standard: A study demonstrated the application of Clozapine-D₄ as an isotopic internal standard in the quantitative LC-MS/MS therapeutic drug monitoring of clozapine and its metabolite norclozapine. This approach significantly enhances the accuracy of pharmacokinetic studies in psychiatric medicine, supporting clinicians in optimizing dosage for better therapeutic outcomes (Couchman et al., 2013).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Clozaril is a registered trademark of Sandoz, Inc.

FazaClo is a registered trademark of Jazz Pharmaceuticals International III Limited

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup