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B2761

Sigma-Aldrich

5-Bromoindole-2-carboxylic acid

98%

Synonym(s):

NSC 73384

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About This Item

Linear Formula:
C9H6NO2Br
CAS Number:
7254-19-5
Molecular Weight:
240.05
MDL number:
MFCD00022705
UNSPSC Code:
12352100
PubChem Substance ID:
57653927
NACRES:
NA.22

Assay

98%

form

powder

storage temp.

−20°C

SMILES string

OC(=O)c1cc2cc(Br)ccc2[nH]1

InChI

1S/C9H6BrNO2/c10-6-1-2-7-5(3-6)4-8(11-7)9(12)13/h1-4,11H,(H,12,13)

InChI key

YAULOOYNCJDPPU-UHFFFAOYSA-N

Application

Reactant involved in studies of biologically active molecules including:
  • Discovery of indole inhibitors of MMP-13 for treatment of arthritic diseases
  • Synthesis of indolyl ethanones as indoleamine 2,3-dioxygenase inhibitors
  • cis-Diaminocyclohexane derivatives prepared for use as factor Xa inhibitors
  • Synthesis of tubulin polymerization inhibitors and cancer cell growth inhibitors
  • Preparation of dual PPARγ/δ agonists
  • Synthesis of chemical probes to examine the role of hFPRL1 receptor in inflammation

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Shahrbanoo Jahangir et al.
Stem cell research & therapy, 11(1), 436-436 (2020-10-11)
Mesenchymal stem cells are a promising cell source for chondrogenic differentiation and have been widely used in several preclinical and clinical studies. However, they are prone to an unwanted differentiation process towards hypertrophy that limits their therapeutic efficacy. Matrix metallopeptidase

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