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About This Item
Empirical Formula (Hill Notation):
C19H22N6O6
CAS Number:
Molecular Weight:
430.41
UNSPSC Code:
51471602
NACRES:
NA.21
MDL number:
Assay:
≥95%
Form:
powder
Pricing and availability is not currently available.
ligand
pomalidomide
Quality Segment
assay
≥95%
form
powder
technique(s)
targeted protein degradation: suitable
functional group
azide
storage temp.
2-8°C
Application
Pomalidomide-PEG2-C2-azide is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Contains an alkyne, allowing for conjugation through click chemistry. A basic building block for development of a protein degrader library.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Other Notes
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
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This Item | |||
|---|---|---|---|
| description ≥95% | description ≥95.0% | description ≥95% | description ≥95% |
| assay ≥95% | assay ≥95.0% | assay ≥95% | assay ≥95% |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 200 |
| form powder | form powder | form powder or crystals | form powder or solid |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| technique(s) targeted protein degradation: suitable | technique(s) targeted protein degradation: suitable | technique(s) targeted protein degradation: suitable | technique(s) targeted protein degradation: suitable |
| functional group azide | functional group azide | functional group alkyne | functional group azide |
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
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