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Sigma-Aldrich

Regenerez® Poly(glycerol sebacate) Resin

Synonym(s):

PGS, Poly(glycerol sebacic acid)

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About This Item

Linear Formula:
(C13H22O5)n
UNSPSC Code:
12352200

form

paste

Quality Level

100

transition temp

flash point >230 °F

storage temp.

−20°C

Application

Regenerez® Poly(glycerol sebacate) is a bioresorbable elastomer. The physical properties can be tuned from an elastomer to a thermoset(U.S. Patent No. 9.359,472) by curing PGS to the desired level of cross-linking. The inherent elastomeric properties of PGS can be used in a variety of applications in regenerative medicine and tissue engineering.

Features and Benefits

  • Bioresorbable.
  • Comprised of naturally occurring metabolites (glycerol and sebacic acid).
  • Tunable mechanical properties.
  • Versatile platform for further modification.
  • Closely simulates modulus of human tissue.
  • Enables healing without harmful immune response.

Legal Information

U.S. Patent No. 9,359,472.
Regenerez is a registered trademark of The Secant Group, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Samer H Zaky et al.
Biomedical materials (Bristol, England), 9(2), 025003-025003 (2014-02-04)
For bone engineering, the optimal scaffolding material and composition has yet to be elucidated. In this study, we investigated poly (glycerol sebacate) (PGS), an elastomer known primarily for its soft tissue regeneration ability, as a suitable substrate to support osteo-precursor
Qi-Zhi Chen et al.
Journal of the mechanical behavior of biomedical materials, 4(8), 1805-1818 (2011-11-22)
Poly (glycerol sebacate) (PGS) is a promising elastomer for use in soft tissue engineering. However, it is difficult to achieve with PGS a satisfactory balance of mechanical compliance and degradation rate that meet the requirements of soft tissue engineering. In
Wei Wu et al.
Nature medicine, 18(7), 1148-1153 (2012-06-26)
Host remodeling is important for the success of medical implants, including vascular substitutes. Synthetic and tissue-engineered grafts have yet to show clinical effectiveness in arteries smaller than 5 mm in diameter. We designed cell-free biodegradable elastomeric grafts that degrade rapidly
Coral Salvo-Comino et al.
Sensors (Basel, Switzerland), 21(3) (2021-02-13)
The integration of nanomaterials as electron mediators in electrochemical biosensors is taking on an essential role. Due to their high surface-to-volume ratio and high conductivity, metallic nanowires are an interesting option. In this paper, silver nanowires (AgNWs) were exploited to
Cathryn A Sundback et al.
Biomaterials, 26(27), 5454-5464 (2005-04-30)
No satisfactory method currently exists for bridging neural defects. Autografts lead to inadequate functional recovery, and most available artificial neural conduits possess unfavorable swelling and pro-inflammatory characteristics. This study examined the biocompatibility of a novel biodegradable elastomer, poly(glycerol sebacate) (PGS)
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