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328936

Sigma-Aldrich

2,3,5,6-Tetrafluorobenzaldehyde

97%

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About This Item

Linear Formula:
HC6F4CHO
CAS Number:
Molecular Weight:
178.08
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

97%

form

liquid

refractive index

n20/D 1.469 (lit.)

bp

178 °C (lit.)

density

1.525 g/mL at 25 °C (lit.)

SMILES string

Fc1cc(F)c(F)c(C=O)c1F

InChI

1S/C7H2F4O/c8-4-1-5(9)7(11)3(2-12)6(4)10/h1-2H

InChI key

YIRYOMXPMOLQSO-UHFFFAOYSA-N

General description

2,3,5,6-Tetrafluorobenzaldehyde is a polysubstituted benzaldehyde and was evaluated as a substrate of PmHNL (Prunus mume hydroxynitrile lyase). Reaction of 2,3,5,6-tetrafluorobenzaldehyde with dipyrromethane was reported.

Application

2,3,5,6-Tetrafluorobenzaldehyde was used in the preparation of 1,3-bis(2,4,6-trimethylphenyl)-2-(2,3,5,6-tetrafluorophenyl)imidazolidine and 1,3-dimethyl-2-(2,3,5,6-tetrafluorophenyl)imidazolidine.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

165.2 °F - closed cup

Flash Point(C)

74 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Gregory W Nyce et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 10(16), 4073-4079 (2004-08-19)
The synthesis of N-heterocyclic carbene (NHC) adducts by condensation of diamines with appropriately substituted benzaldehydes is described. This simplified approach provides the NHC adduct without first having to generate the carbene followed by its protection. These adducts undergo thermal deprotection
Effects of aldehyde or dipyrromethane substituents on the reaction course leading to meso-substituted porphyrins.
Geier III, et al.
Tetrahedron, 60(50), 11435-11444 (2004)
A new (R)-hydroxynitrile lyase from< i> Prunus mume</i>: asymmetric synthesis of cyanohydrins.
Nanda S, et al.
Tetrahedron, 61(46), 10908-10916 (2005)

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