SRP0353

Akt1 active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE)

• Synonyma: PKB, RAC, v-akt murine thymoma viral oncogene homolog 1
• NACRES: NA.32
• UNSPSC Code: 12352202
• Assay: ≥75% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in baculovirus infected Sf9 cells

Vlastnosti

• biological source: human
• recombinant: expressed in baculovirus infected Sf9 cells
• assay: ≥75% (SDS-PAGE)
• form: aqueous solution
• mol wt: 60.2 kDa
• packaging: pkg of 10 μg
• NCBI accession no.: NM_001014432
• UniProt accession no.: P31749
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... AKT1(207)

Popis

General description

AKT1 (v-akt murine thymoma viral oncogene homolog 1) is a Ser/Thr protein kinase, and is also called protein kinase B (PKB). This protein is activated when it is phosphorylated at serine 473 and threonine 308. This gene is localized to human chromosome 14q32.32.

Application

Akt1 active human has been used for the testing of recombinant mouse p21 proteins as its substrates using in vitro protein kinase assay.

Biochem/physiol Actions

AKT1 (v-akt murine thymoma viral oncogene homolog 1) is responsible for the phosphorylation and cytoplasmic localization of CKDN1A (cyclin-dependent kinase (CDK) inhibitor 1, also referred to as p21). However, p21 is one of the CDKNs which normally resides in the nucleus and its cytoplasmic localization, mediated by AKT1, is common to various cancers where it suppresses proteins essential for apoptosis. Studies show that up-regulation of AKT1 serves as a poor prognostic marker in breast cancer, which however, depends upon factors including population, hormone receptor status, and hormonal or trastuzumab therapy status.

Bezpečnostní informace

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H315,H319,H360D
• pcodes: P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
• Skladovací třída: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable