SML3620

UNC2250

≥98% (HPLC)

• Synonyma: UNC 2250, UNC-2250, trans-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol
• Empirický vzorec (Hillův zápis): C₂₄H₃₆N₆O₂
• Číslo CAS: 1493694-70-4
• Molekulová hmotnost: 440.58
• UNSPSC Code: 12352200
• NACRES: NA.25
• MDL number: MFCD27992060
• Assay: ≥98% (HPLC)
• Form: powder

Vlastnosti

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: -10 to -25°C
• SMILES string: N4(CCOCC4)Cc1cnc(cc1)c2c(nc(nc2)NCCCC)N[C@@H]3CC[C@H](CC3)O
• InChI key: HSYSSKFCQHXOBP-MXVIHJGJSA-N

Popis

Biochem/physiol Actions

Potent and highly selective Mer receptor tyrosine kinase (MerTK) inhibitor in vitro and in vivo.

UNC2250 is a potent and highly selective Mer receptor tyrosine kinase inhibitor (MerTK IC50 = 1.7 nM; Tyro3/Axl IC50 = 100/270 nM) that reduces endogenous Mer phosphorylation level (697 B-ALL IC50 = 9.8 nM post 1h treatment) and blocks ligand-stimulated activation of a chimeric EGFR-Mer in cells. UNC2250 inhibits colony-forming potential in rhabdoid (by 36% at 100 nM; BT-12 cells) and NSCLC tumor cells (Colo699 IC50 = 100 nM) with good pharmacokinetic properties. UNC2250 is reported to reduce mortality in a murine LPS-induced acute lung injury (ALI) model (2 mg/kg i.v. )

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable