SML2904

AGF347

≥98% (HPLC)

• Synonyma: (4-(4-(2-Amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl)-2-fluorobenzoyl)-L-glutamic acid, (S)-2-(4-(4-(2-Amino-4-oxo-3H-pyrrolo[3,2-d]pyrimidin-5(4H)-yl)butyl)-2-fluorobenzamido)pentanedioic acid, N-[4-[4-(2-Amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]-L-glutamic acid
• Empirický vzorec (Hillův zápis): C₂₂H₂₄FN₅O₆
• Číslo CAS: 2294820-23-6
• Molekulová hmotnost: 473.45
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Vlastnosti

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/L, clear
• storage temp.: 2-8°C
• SMILES string: O=C(CC[C@H](NC(C1=CC=C(C=C1F)CCCCN2C=CC(N=C(N3)N)=C2C3=O)=O)C(O)=O)O

Popis

Biochem/physiol Actions

AGF347 is a potent inhibitor of serine hydroxymethyltransferase 2 (SHMT2) that inhibits mitochondrial C1 metabolism. It also inhibits cytosolic C1 targets such as SHMT1, GARFTase, and AICARFTase. AGF347 inhibits de novo purine biosynthesis. AGF347 exhibits potent broad spectrum in vitro and in vivo antitumor efficacy.

potent inhibitor of serine hydroxymethyltransferase 2 (SHMT2)

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3