SML2494

Pralatrexate

≥98% (HPLC), DHFR inhibitor, powder

• Synonyma: (2S)-2-[[4-[(1RS)-1-[(2,4-diaminopteridin-6-yl)methyl]but-3-ynyl]benzoyl]amino]pentanedioic acid, 10-propargyl-10-deazaaminopterin, N-(4-{1-[(2,4-diaminopteridin-6-yl)methyl]but-3-yn-1-yl}benzoyl)-L-glutamic acid, PDX
• Empirický vzorec (Hillův zápis): C₂₃H₂₃N₇O₅
• Číslo CAS: 146464-95-1
• Molekulová hmotnost: 477.47
• NACRES: NA.77
• UNSPSC Code: 12352200
• MDL number: MFCD00920897
• Assay: ≥98% (HPLC)
• Form: powder

Vlastnosti

• Název produktu: Pralatrexate, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL
• storage temp.: −20°C
• SMILES string: O=C([C@@H](NC(C1=CC=C(C(CC(N=C23)=CN=C3N=C(N=C2N)N)CC#C)C=C1)=O)CCC(O)=O)O
• InChI: 1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,28,33)(H,31,32)(H,34,35)(H4,24,25,26,29,30)/t14?,16-/m0/s1
• InChI key: OGSBUKJUDHAQEA-WMCAAGNKSA-N

Popis

Biochem/physiol Actions

Potent DHFR inhibitor; antifolate; antineoplastic;

Pralatrexate is an antifolate that selectively enters cancer cells expressing reduced folate carrier type 1 (RFC-1). Pralatrexate potently inhibits DHFR (dihydrofolate reductase).

Bezpečnostní informace

• pictograms: GHS08
• signalword: Warning
• hcodes: H361fd
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable