SML0370

Kartogenin

≥98% (HPLC), runt-related transcription factor 1 (RUNX1) regulator, powder

• Synonyma: 2-[(Biphenyl-4-yl)carbamoyl]benzoic acid, 4′-Phenyl-phthalanilic acid (8CI), KGN
• Empirický vzorec (Hillův zápis): C₂₀H₁₅NO₃
• Číslo CAS: 4727-31-5
• Molekulová hmotnost: 317.34
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825371
• NACRES: NA.77
• MDL number: MFCD00560510
• Assay: ≥98% (HPLC)
• Form: powder

Vlastnosti

• Název produktu: Kartogenin, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: >15 mg/mL
• storage temp.: room temp
• SMILES string: O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)C(C=CC=C3)=C3C(O)=O
• InChI: 1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
• InChI key: SLUINPGXGFUMLL-UHFFFAOYSA-N

Popis

Biochem/physiol Actions

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes.

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.

Kartogenin is a small heterocyclic compound. It is involved in regulating runt-related transcription factor 1 (RUNX1), which plays an important role in chondrocyte proliferation and survival.

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3