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Key Documents

SAB3500340

Sigma-Aldrich

Anti-PTK7 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyma:

Anti-CCK-4, Anti-Colon carcinoma kinase-4, Anti-Protein tyrosine Kinase 7

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen


About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PTK7(5754)

General description

Protein tyrosine kinase-7 (PTK7) is a transmembrane receptor, that belongs to the receptor protein tyrosine kinase (RTKs) family. It has an extracellular immunoglobulin-like domain, a transmembrane domain and an inert tyrosine kinase-like domain. PTK7 is located on human chromosome 6p21.

Immunogen

PTK7 antibody was raised against a 18 amino acid peptide from near the carboxy terminus of human PTK7.

Application

Anti-PTK7 antibody has been used in immunohistochemistry.

Biochem/physiol Actions

Protein tyrosine kinase-7 (PTK7) stimulates cell proliferation and invasion. It plays a vital role embryonic development and disease. PTK7 controls radioresistance with the help of nuclear factor-κ B in esophageal squamous cell carcinoma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500340.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Č. produktu
Popis
Stanovení ceny

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Osvědčení o analýze (COA)

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Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.

Navštívit knihovnu dokumentů

PTK7 overexpression in colorectal tumors: Clinicopathological correlation and prognosis relevance.
Tian X, et al.
Oncology Reports, 36(4), 1829-1836 (2016)
A meta-analysis of lung cancer gene expression identifies PTK7 as a survival gene in lung adenocarcinoma.
Chen R, Khatri P, Mazur PK, et al.
Cancer Research, 74(10), 2892-2902 (2014)
PTK7 is a novel oncogenic target for esophageal squamous cell carcinoma.
Liu K, et al.
World Journal of Surgical Oncology, 15(1), 105-105 (2017)
PTK7 localization and protein stability is affected by canonical Wnt ligands.
Berger H, et al.
Journal of Cell Science, 130(11), 1890-1903 (2017)
Yi Lin et al.
Journal of surgical oncology, 106(7), 880-886 (2012-05-16)
Protein tyrosine kinase 7 (PTK7) plays important functions in several cancer types but its expression in gastric cancer remains unknown. This study was designed to investigate PTK7 expression in gastric cancer. PTK7 expression was assessed by immunohistochemistry in 201 gastric

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