PZ0198

Prinomastat hydrochloride

≥95% (HPLC), MMP inhibitor, powder

• Synonyma: (S)-2,2-Dimethyl-4-((p-(4-pyridyloxy)phenyl)sulfonyl)-3-thiomorpholinecarbohydroxamic acid hydrochloride, AG 3340 hydrochloride, AG-3340 hydrochloride, AG3340 hydrochloride
• Empirický vzorec (Hillův zápis): C₁₈H₂₁N₃O₅S₂ · HCl
• Číslo CAS: 192329-42-3
• Molekulová hmotnost: 459.97
• UNSPSC Code: 12352200
• PubChem Substance ID: 329823770
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

Vlastnosti

• Název produktu: Prinomastat hydrochloride, ≥95% (HPLC)
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 15 mg/mL (clear solution)
• storage temp.: room temp
• SMILES string: Cl.CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c2ccc(Oc3ccncc3)cc2
• InChI: 1S/C18H21N3O5S2.ClH/c1-18(2)16(17(22)20-23)21(11-12-27-18)28(24,25)15-5-3-13(4-6-15)26-14-7-9-19-10-8-14;/h3-10,16,23H,11-12H2,1-2H3,(H,20,22);1H/t16-;/m0./s1
• InChI key: UQGWXXLNXBRNBU-NTISSMGPSA-N

Popis

General description

Prinomastat comprises hydroxamic acid group and chelates with zinc ion.PMID 25667046

Application

Prinomastat hydrochloride has been used as an antagonist for metalloproteinases (MMPs) in Crotalus atrox venom samplesPMID 12225776 and mouse embryo cultures.PMID 12508050 It may be used as a MMP-2 inhibitor in HepG2 cells.PMID 28883413

Biochem/physiol Actions

Prinomastat is a matrix metalloprotease (MMP) inhibitor with selectivity for MMPs 2, 3, 9, 13, and 14. Inhibition of these MMPs has been postulated to block tumor invasion and metastasis. It is extremely potent at MMP-3 and MMP-2 with IC₅₀s, 30 pM & 50 pM, respectively.

Prinomastat is a matrix metalloprotease (MMP) inhibitor.

Bezpečnostní informace

• pictograms: GHS08
• signalword: Danger
• hcodes: H360
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable