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N1142

Neomycin

Name: Neomycin
Brand: SIGMA
Price: 836 CZK

solution, suitable for cell culture, BioReagent

Synonyma:

Antibiotic 10676, Neomycin B

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Vám/Skladová položka	Dostupnost	Cena
20 mL	Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.	836,00 Kč

O této položce

UNSPSC Code:

12352207

PubChem Substance ID:

24897464

NACRES:

NA.76

836,00 Kč

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Vlastnosti

Název produktu

Neomycin solution, with 10 mg/mL neomycin in 0.9% NaCl, 0.1 μm filtered, BioReagent, suitable for cell culture

biological source

Streptomyces fradiae

Quality Segment

200

sterility

0.1 μm filtered

product line

BioReagent

form

liquid

potency

8-12 mg per mL

packaging

pkg of 20ML

concentration

10 mg/mL in 0.9% NaCl (neomycin)

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

clear

UniProt accession no.

O14746

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)[C@H](N)[C@@H](O)[C@@H]1O

InChI

1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

InChI key

PGBHMTALBVVCIT-VCIWKGPPSA-N

Gene Information

human ... TERT(7015)

Popis

General description

Chemical structure: aminoglycoside

Application

Neomycin solution has been used:

as a supplement of autoclaved acidified water for bone marrow transplantation
for the selection of stable clones
as a component of artificial sea water (ASWO) medium to remove bacteria from O. tauri cultures

Biochem/physiol Actions

Neomycin is an aminoglycoside antibiotic, produced by Streptomyces containing a minimum of 85% neomycin B. It acts as a selection agent for prokaryotic cells transformed using the neo selectable marker gene. Neomycin trisulfate is used to study the cytototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts and extraction of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins. This product is recommended for use in cell culture applications at 5 mL/L.
Mode of action: This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca²⁺ channels without affecting the Na⁺/Ca²⁺ antiporter in neurons.
Antimicrobial spectrum: Neomycin acts against both gram-positive and gram-negative bacteria

Disclaimer

This solution is formulated to contain 10 mg/mL neomycin in 0.9% sodium chloride. It is stable at 37 °C for 5 days and should be otherwise stored at 2-8°C.

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Tato položka	N6386	K0129	G1272
Sigma-Aldrich N1142 Neomycin solution	Sigma-Aldrich N6386 Neomycin trisulfate salt hydrate	Sigma-Aldrich K0129 Kanamycin solution from Streptomyces kanamyceticus	Sigma-Aldrich G1272 Gentamicin solution
description with 10 mg/mL neomycin in 0.9% NaCl, 0.1 μm filtered, BioReagent, suitable for cell culture	description powder, BioReagent, suitable for cell culture	description 10 mg/mL in 0.9% NaCl, 0.1 μm filtered, BioReagent, suitable for cell culture	description 10 mg/mL in deionized water, liquid, 0.1 μm filtered, BioReagent, suitable for cell culture
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable, cell culture \| plant: suitable	technique(s) cell culture \| mammalian: suitable
antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycoplasma
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 300
product line BioReagent	product line BioReagent	product line BioReagent	product line BioReagent
form liquid	form powder	form liquid	form liquid
concentration 10 mg/mL in 0.9% NaCl (neomycin)	concentration -	concentration 10 mg/mL in 0.9% NaCl	concentration 10 mg/mL in deionized water

pictograms

GHS08

signalword

Danger

hcodes

H317,H334

pcodes

P261 - P280 - P284 - P304 + P340 - P333 + P313 - P342 + P311

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Skladovací třída

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c