GW22681

Anti-MUC1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD00213000
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC, WB
• Citations: 5

Vlastnosti

• biological source: chicken
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human, mouse, rat
• manufacturer/tradename: Genway 15-288-22681
• technique(s): immunohistochemistry: suitable, western blot: suitable
• NCBI accession no.: NP_002447.4
• UniProt accession no.: P15941
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MUC1(4582)

Popis

General description

Mucin 1 (MUC1) is a O-glycosylated, membrane bound, transmembrane glycoprotein belonging to the mucin (MUC) gene family. It is expressed on the apical surface of mucosal epithelia in the lung, eye, breast and stomach. It consists of an N-terminal extracellular domain consisting of variable number tandem repeats (MUC1-TR) of 20 amino acids (aa) and a C-terminal domain which includes a 53aa extracellular region, a transmembrane domain (TM) and a 72aa cytoplasmic tail (MUC1CT).

Immunogen

Immunogen Sequence: GI # 65301117, sequence 199-244

Recombinant MUC1 mucin isoform 1

Application

Anti-MUC1 antibody produced in chicken is suitbale for immunohistochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Mucin 1, cell surface associated (MUC1), plays an important role in the cell signaling during cancer progression. It carries tumor-associated epitopes and is aberrantly expressed in tumors. MUC1 plays a crucial role in the development, progression of breast cancer and could promote the invasion ability of breast cancer cells. Mutation in the gene may result in progressive chronic kidney failure with a bland urinary sediment.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Bezpečnostní informace

• Skladovací třída: 10 - Combustible liquids
• Co se děje?: WGK 1
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable
• PPE (osobní ochranné prostředky): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)