G4923

(E)-Guggulsterone

≥95% (HPLC), powder

• Synonyma: (17E)-Pregna-4,17(20)-diene-3,16-dione
• Empirický vzorec (Hillův zápis): C₂₁H₂₈O₂
• Číslo CAS: 39025-24-6
• Molekulová hmotnost: 312.45
• NACRES: NA.77
• PubChem Substance ID: 329799934
• UNSPSC Code: 12352205
• MDL number: MFCD01310758

Vlastnosti

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: soluble 5 mg/mL
• functional group: ketone
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: C\C=C1\C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4-/t15-,17+,18+,20+,21-/m1/s1
• InChI key: WDXRGPWQVHZTQJ-AUKWTSKRSA-N

Popis

Biochem/physiol Actions

Naturally occuring bioactive plant sterol isolated from the gum resin of guggul (Commiphora wightii). Antihyperlipidemic. Induces the expression of human CYP3A.

Naturally occuring bioactive plant sterol isolated from the gum resin of guggul (Commiphora wightii). Antihyperlipidemic. Induces the expression of human CYP3A.. Guggulsterone potently reverses multi-drug resistance in a number of human cancer cell lines, extending the efficacy of chemotherapy.

Bezpečnostní informace

• pictograms: GHS07
• signalword: Warning
• hcodes: H335,H412
• pcodes: P261 - P271 - P273 - P304 + P340 + P312 - P403 + P233 - P405
• Hazard Classifications: Aquatic Chronic 3 - STOT SE 3
• target_organs: Respiratory system
• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable