C2505

Corticosterone

≥92% (HPLC), powder, corticosteroid hormone

• Synonyma: 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
• Empirický vzorec (Hillův zápis): C₂₁H₃₀O₄
• Číslo CAS: 50-22-6
• Molekulová hmotnost: 346.46
• NACRES: NA.77
• PubChem Substance ID: 24278302
• UNSPSC Code: 51111800
• EC Number: 200-019-6
• MDL number: MFCD00037715
• Beilstein/REAXYS Number: 2339601
• Assay: ≥92%
• Form: powder

Vlastnosti

• Název produktu: Corticosterone, ≥92%
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥92%
• form: powder
• mp: 179-183 °C (lit.)
• solubility: chloroform: 50 mg/mL, clear, colorless to faintly yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• InChI key: OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• Gene Information: human ... EBP(10682), SERPINA6(866) ; rat ... Ar(24208), Nr3c1(24413)

Popis

Application

Corticosterone has been used:

• in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice
• as a stress inducing hormone in pregnant mice
• to test its effect on depression-related behaviors in mice

Biochem/physiol Actions

Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.

Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands. However, it may also be synthesized in non-adrenal tissues including leydig cells of testes and in murine thymus. Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress. It is produced by HPA activation in response to stress in myeloid cells. Elevated levels of corticosterone is observed in Huntington′s disease (HD).

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves