A5486

Azoxymethane

13.4 M, ≥98%

• Synonyma: AOM
• Lineární vzorec: CH₃N=N(→O)CH₃
• Číslo CAS: 25843-45-2
• Molekulová hmotnost: 74.08
• MDL number: MFCD00126912
• UNSPSC Code: 12352124
• PubChem Substance ID: 329770827
• NACRES: NA.25

Vlastnosti

• assay: ≥98%
• form: liquid
• composition: methylene chloride, ≤1% (solvent)
• storage condition: (Keep container tightly closed in a dry and well-ventilated place.)
• concentration: 13.4 M
• color: colorless
• bp: 97-99 °C (lit.)
• density: 0.991 g/mL at 25 °C (lit.)
• application(s): genomic analysis
• storage temp.: −20°C
• SMILES string: C\N=[N+](/C)[O-]
• InChI: 1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+
• InChI key: DGAKHGXRMXWHBX-ONEGZZNKSA-N

Popis

General description

Azoxymethane (AOM) is a potent laboratory chemical used to study cancer initiation, progression, and prevention, particularly in the colon. It acts as both a carcinogen, triggering tumor formation, and a gene mutation agent, causing specific alterations in DNA.

Application

Azoxymethane (AOM), a gene mutation agent, may be used with dextran sulfate sodium (DSS) to create cancer models in laboratory animals which can be used to study mechanisms of cancer progression and chemoprevention.

Biochem/physiol Actions

Carcinogen that induces O⁶-methylguanine adducts in DNA leading to G→A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism of cancer progression and chemoprevention.

Features and Benefits

Versatile and adaptable for a wide variety of laboratory and research applications.

Other Notes

For additional information on our range of Biochemicals, please complete this form.

It is critical to determine the correct dosage of Azoxymethane for the experimental design to avoid premature death of laboratory animals.

Bezpečnostní informace

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H226,H300,H315,H319,H350
• pcodes: P202 - P210 - P233 - P301 + P310 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 75.2 °F
• flash_point_c: 24 °C