A4393

R-(−)-Apomorphine hydrochloride hemihydrate

calcined, ≥98% (with NaOH, titration)

• Lineární vzorec: C₁₇H₁₇NO₂ · HCl · 1/2H₂O
• Číslo CAS: 41372-20-7
• Molekulová hmotnost: 312.79
• NACRES: NA.77
• PubChem Substance ID: 24278821
• UNSPSC Code: 12352210
• EC Number: 206-243-0
• MDL number: MFCD00150904
• Assay: ≥98% (with NaOH, titration)
• Form: calcined, (Powder to Crystalline Powder)
• Storage condition: protect from light, under inert gas

Vlastnosti

• Quality Segment: 200
• assay: ≥98% (with NaOH, titration)
• form: calcined, (Powder to Crystalline Powder)
• storage condition: protect from light, under inert gas
• color: white to gray
• mp: 285-287 °C (lit.)
• solubility: H₂O: ~10 mg/mL, clear, yellow-green
• SMILES string: Cl[H].Cl[H].[H]O[H].[H][C@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1C)c24.[H][C@]56Cc7ccc(O)c(O)c7-c8cccc(CCN5C)c68
• InChI: 1S/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1
• InChI key: CXWQXGNFZLHLHQ-DPFCLETOSA-N
• Gene Information: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Popis

Application

R-(-)-Apomorphine hydrochloride hemihydrate has been used as a dopamine receptor agonist to study its effects of rotational behavior in rat models of Parkinson′s disease.

Biochem/physiol Actions

R-(−)-Apomorphine acts as a non-selective D1 and D2 dopamine receptor agonist. It shows therapeutic effects against Parkinson′s disease and male erectile dysfunction. R-(−)-Apomorphine also shows neuroprotective, radical scavenging, and emetic effects. Apomorphine stimulates the brain chemoreceptor trigger zone. It stimulates the chemoreceptor trigger zone in the brain.

Bezpečnostní informace

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves