SMB00975

Bisdesethylchloroquine Hydrochloride

• Synonyma: Bisdesethyl chloroquine hydrochloride, Didesethylchloroquine hydrochloride
• Empirický vzorec (Hillův zápis): C₁₄H₁₈ClN₃ · xHCl
• Molekulová hmotnost: 263.77 (free base basis)
• UNSPSC Code: 41116105
• NACRES: NA.77
• MDL number: MFCD00871854
• Assay: ≥95% (HPLC)
• Form: solid

Vlastnosti

• assay: ≥95% (HPLC)
• Quality Segment: 200
• form: solid
• storage temp.: 2-8°C
• SMILES string: Clc1cc2nccc(c2cc1)NC(CCCN)C
• InChI: 1S/C14H18ClN3/c1-10(3-2-7-16)18-13-6-8-17-14-9-11(15)4-5-12(13)14/h4-6,8-10H,2-3,7,16H2,1H3,(H,17,18)
• InChI key: GYEDIFVVTRKXHP-UHFFFAOYSA-N

Popis

General description

Bisdesethylchloroquine is an immediate metabolite of hydroxychloroquine and chloroquine. These are antimalarial drugs used clinically in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. These drugs interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production and certain co-stimulatory molecules. Hydroxychloroquine and chloroquine mode(s) of action are still emerging and their metabolism are of great interest. Metabolic Pathway: Cytochrome P450 drug.

Application

Metabolomics research

Other Notes

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Bezpečnostní informace

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable