SMB00947

N-Desethyl amodiaquine dihydrochloride

≥95%

• Synonyma: Monodesethylamodiaquine dihydrochloride
• Empirický vzorec (Hillův zápis): C₁₈H₁₈ClN₃O · 2HCl
• Číslo CAS: 79049-30-2
• Molekulová hmotnost: 400.73
• NACRES: NA.77
• UNSPSC Code: 41116107
• Assay: ≥95%
• Form: solid

Vlastnosti

• biological source: synthetic
• Quality Segment: 200
• assay: ≥95%
• form: solid
• mol wt: 400.73 g/mol
• technique(s): HPLC: suitable
• color: yellow to dark yellow
• solubility: DMSO: soluble, methanol: soluble, water: soluble
• storage temp.: 2-8°C

Popis

Application

Amodiaquine (AQ) is currently used in combination with Artesunate (AS) as first-line treatment for some cases of falciparum malaria (UM) in many countries. AQ is metabolized by hepatic cytochrome P450 2C8 (CYP2C8) to Desethylamodiaquine (DAQ; DEAQ; NADQ; Ndes-amo), which is subsequently eliminated via extra-hepatic biotransformation by CYP1A1 and CYP1B1. DEAQ is responsible for the pharmacological activity of AQ (both therapeutic and toxicity) due to its long elimination half-life.

Metabolomics research

Other Notes

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Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• Co se děje?: WGK 3
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable