10107409001

Mitomycin C

crystalline powder, 98%, pkg of 2 mg

• Synonyma: Mitomycin C
• Empirický vzorec (Hillův zápis): C₁₅H₁₈N₄O₅
• Číslo CAS: 50-07-7
• Molekulová hmotnost: 334.33
• MDL number: MFCD00078109
• UNSPSC Code: 12352207
• NACRES: NA.54

Vlastnosti

• assay: 98%
• form: crystalline powder
• mol wt: 334.3
• packaging: pkg of 2 mg
• manufacturer/tradename: Roche
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: DNA synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: N21[C@]([C@H]4N[C@H]4C2)([C@@H](C3=C1C(=O)C(=C(C3=O)N)C)COC(=O)N)OC
• InChI: 1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
• InChI key: NWIBSHFKIJFRCO-WUDYKRTCSA-N

Popis

General description

Mitomycin C is an antitumor antibiotic.[1]

Application

Mitomycin C is used as an inhibitor for studies of cell-free protein biosynthesis. It also inhibits DNA synthesis. It has been used as a genotoxic agent for tumor cells.[2]

Mitomycin C has been used:

• to cease mitosis
• in phosphate buffer saline (PBS) for inactivation and plating mouse embryonic fibroblasts (MEFs)
• as mutagen in mutagenicity assay

Biochem/physiol Actions

Mitomycin C (MMC) acts as a prototype for drugs with bioreductive alkylation. It is mainly found to be active under anaerobic conditions. MMC exhibits a vast clinical antitumor spectrum effectively in gastric, pancreatic and breast cancer.

Other Notes

For life science research only. Not for use in diagnostic procedures.

Bezpečnostní informace

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300,H351
• pcodes: P201 - P264 - P280 - P301 + P310 + P330 - P308 + P313 - P501
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 2
• Skladovací třída: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: does not flash
• flash_point_c: does not flash