5.08514

Psalmotoxin-1

• Synonyma: Psalmotoxin-1, ASIC1a Inhibitor, Psalmotoxin 1
• Empirický vzorec (Hillův zápis): C₂₀₀H₃₁₂N₆₂O₅₇S₆
• Číslo CAS: 316808-68-1
• Molekulová hmotnost: 4689.39
• MDL number: MFCD00004691
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥94% (HPLC)
• Form: semisolid, viscous liquid
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Vlastnosti

• assay: ≥94% (HPLC)
• Quality Segment: 100
• form: semisolid, viscous liquid
• potency: 0.9 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• color: colorless
• storage temp.: −20°C

Popis

General description

A potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC₅₀ = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.

Biochem/physiol Actions

Primary Target
ASIC1a

Other Notes

EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)

Qadri, Y. J. et al. 2009. J. Biol. Chem.284, 17625.
M. Mazzuca, et al. 2007. Nat Neurosci.10, 943.
Escoubas, P. et al. 2000. J. Biol. Chem.275, 25116.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable