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Merck
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399275

Sigma-Aldrich

Nω-Hydroxy-nor-L-arginine, Diacetate Salt

A potent, selective, competitive, and high affinity inhibitor of arginase.

Synonyma:

Nω-Hydroxy-nor-L-arginine, Diacetate Salt, nor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H

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About This Item

Empirický vzorec (Hillův zápis):
C5H12N4O3 · 2C2H4O2
Číslo CAS:
189302-40-7
Molekulová hmotnost:
296.28
MDL number:
MFCD01318777
UNSPSC Code:
12352209
NACRES:
NA.77

Quality Level

100

assay

≥97% (TLC)

form

solid

potency

2 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

off-white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

N(O)\C(=N\CC[C@H](N)C(=O)O)\N.OC(=O)C.OC(=O)C

InChI key

PQFYTZJPYBMTCT-QTNFYWBSSA-N

General description

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.

Biochem/physiol Actions

Primary Target
arginase from rat liver
Secondary Target
mouse macrophages (IC₅₀ = 50 µM)

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
Moali, C., et al. 2000. Biochemistry 39, 8208.
Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
Moali, C., et al. 1998. Biochemistry 37, 10453.
Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Osvědčení o analýze (COA)

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