399275

Nω-Hydroxy-nor-L-arginine diacetate Salt

≥97% (TLC), Arginase inhibitor, solid

• Synonyma: N^ω-Hydroxy-nor-L-arginine, Diacetate Salt, nor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H
• Empirický vzorec (Hillův zápis): C₅H₁₂N₄O₃ · 2C₂H₄O₂
• Číslo CAS: 189302-40-7
• Molekulová hmotnost: 296.28
• MDL number: MFCD01318777
• UNSPSC Code: 12352209
• NACRES: NA.77
• Assay: ≥97% (TLC)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic)

Vlastnosti

• Název produktu: N^ω-Hydroxy-nor-L-arginine, Diacetate Salt, A potent, selective, competitive, and high affinity inhibitor of arginase.
• Quality Segment: 100
• assay: ≥97% (TLC)
• form: solid
• potency: 2 μM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: off-white
• solubility: water: 50 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: N(O)\C(=N\CC[C@H](N)C(=O)O)\N.OC(=O)C.OC(=O)C
• InChI key: PQFYTZJPYBMTCT-QTNFYWBSSA-N

Popis

General description

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC₅₀ = 2 µM) and mouse macrophages (IC₅₀ = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.

Biochem/physiol Actions

Primary Target
arginase from rat liver

Secondary Target
mouse macrophages (IC₅₀ = 50 µM)

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
Moali, C., et al. 2000. Biochemistry 39, 8208.
Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
Moali, C., et al. 1998. Biochemistry 37, 10453.
Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable