239765

Cycloheximide

hFKBP12 inhibitor, solution

• Synonyma: InSolution Cycloheximide
• Empirický vzorec (Hillův zápis): C₁₅H₂₃NO₄
• Číslo CAS: 66-81-9
• Molekulová hmotnost: 281.35
• UNSPSC Code: 12352111
• NACRES: NA.77
• MDL number: MFCD00082346
• Form: solution

Vlastnosti

• Název produktu: Cycloheximide, InSolution, 100 mg/mL in DMSO, Suitable for cell culture
• Quality Segment: 100
• form: solution
• manufacturer/tradename: Calbiochem^®
• concentration: 100 mg/mL in DMSO
• solubility: DMSO: soluble
• storage temp.: 2-8°C
• SMILES string: N1C(=O)CC(CC1=O)C[C@@H](O)[C@@H]2C[C@H](C[C@@H](C2=O)C)C
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• InChI key: YPHMISFOHDHNIV-FSZOTQKASA-N

Popis

General description

A convenient ready-to-use form of Cycloheximide (Cat. No. 239763). An anti-fungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Also inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (K_i = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt′s lymphoma cells, and a variety of other cell types, including rodent macrophages. Induces DNA fragmentation in macrophages, but inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.

Biochem/physiol Actions

Primary Target
hFKBP12

Packaging

Packaged under inert gas

Physical form

A 100 mg/ml solution of Cycloheximide (Cat. No. 239763 ) in DMSO (sterile-filtered).

Preparation Note

Following initial use, aliquot and refrigerate (4°C).

Other Notes

Christner, C., et al. 1999. J. Med. Chem.42, 3615.
Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys.334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res.216, 149.
Waring, P. 1990. J. Biol. Chem.265, 14476.
Obrig, T.G., et al. 1971. J. Biol. Chem.246, 174.
Pestka, S. 1971. Annu. Rev. Microbiol.25, 487.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Bezpečnostní informace

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H341,H360D,H412
• pcodes: P202 - P264 - P270 - P273 - P280 - P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 3 - Muta. 2 - Repr. 1B
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3