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Key Documents

129876

Sigma-Aldrich

Amiloride, Hydrochloride

An inhibitor of angiogenesis.

Synonyma:

Amiloride, Hydrochloride, Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen


About This Item

Empirický vzorec (Hillův zápis):
C6H8ClN7O · xHCl
Číslo CAS:
Molekulová hmotnost:
229.63 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

off-white to yellow

solubility

water: 2.5 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H

InChI key

ACHKKGDWZVCSNH-UHFFFAOYSA-N

General description

An inhibitor of angiogenesis. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+/H+ ATPase. Inhibits smooth muscle responses to contractile stimuli. Blocks palytoxin-induced conductance in skeletal muscle. Reduces the electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.
An inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+,K+-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.

Biochem/physiol Actions

Cell permeable: no
Primary Target
capillary morphogenesis
Product does not compete with ATP.
Reversible: yes
Target IC50: 130 µM inhibiting capillary morphogenesis completely and reversibly

Warning

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Knoll, A., et al. 1999. Microvasc. Res.58, 1.
Swiercz, R., et al. 1999. Oncol. Rep.6, 523.
Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
Sugiyama, S., et al. 1988. J. Biol. Chem.263, 8215.
Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun.154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol.250, C175.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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