Přejít k obsahu
Merck

Hlavní dokumenty

Zobrazit celou dokumentaci

Přeskočit na

124030

Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2

The Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonyma:

Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2, N-(2-(Diethylamino)ethyl)-3-(4-((4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-2-phenyl-6-quinolinecarboxamide, 3HCl, N-(2-(Diethylamino)ethyl)-2-(4-((4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-3-phe

Přihlásit pro zobrazení organizačních a smluvních cen.

Vybrat velikost

Změnit zobrazení
Vám/Skladová položkaDostupnostCena
2 mg

Očekávané datum odeslání31. července 2026odAreál Kühne+Nagel spol. s r.o.

8 270,00 Kč

O této položce

Empirický vzorec (Hillův zápis):
C40H43N7O2 · 3HCl
Molekulová hmotnost:
763.20
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥97% (mixture of regioisomers, HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

8 270,00 Kč

Očekávané datum odeslání31. července 2026podrobné informace

​
Technický servis
Potřebujete pomoc? Náš tým zkušených odborníků je vám k dispozici.
Dovolte nám, abychom vám pomohli

Quality Segment

100

assay

≥97% (mixture of regioisomers, HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

yellow

solubility

DMSO: 25 mg/mL, water: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A highly cell-permeable and water soluble analog of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018) that acts as a plecktrin homology (PH)-domain dependent, non-ATP competitive and an allosteric inhibitor of Akt1/2 (IC50 = 560 nM, 390 nM and 7.8 µM in in vitro kinase assay; 526 nM, 730 nM and >10 µM in LNCaP cells for Akt1, Akt2 and Akt3, respectively) with ~ 80-fold greater selectivity over PKA, PKC and SGK (IC50 >50 µM). One of its potent regioisomers (C7-substituted) is shown to enhance induced caspase-3 activity in several tumor cells.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Zhao, Z., et al. 2008. Bioorg. Med. Chem. Lett.18, 49.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Porovnat podobné položky

Zobrazit úplné porovnání

Zobrazit rozdíly

1 of 1

Tato položka
124029124018124017
Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 The Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

124030

Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2

Akt Inhibitor XII, Isozyme-Selective, Akti-2 The Akt Inhibitor XII, Isozyme-Selective, Akti-2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

124029

Akt Inhibitor XII, Isozyme-Selective, Akti-2

Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a cell-permeable, reversible inhibitor of Akt1/Akt2 (IC50 = 58 nM, 210 nM, & 2.12 µM for Akt1, Akt2, and Akt3, respectively).

Sigma-Aldrich

124018

Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2

Akt Inhibitor VIII, Akti-1/2 InSolution, ≥95%, Isozyme-Selective

Sigma-Aldrich

124017

Akt Inhibitor VIII, Akti-1/2

description

The Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

description

The Akt Inhibitor XII, Isozyme-Selective, Akti-2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

description

Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a cell-permeable, reversible inhibitor of Akt1/Akt2 (IC50 = 58 nM, 210 nM, & 2.12 µM for Akt1, Akt2, and Akt3, respectively).

description

InSolution, ≥95%, Isozyme-Selective

assay

≥97% (mixture of regioisomers, HPLC)

assay

≥97% (mixture of regioisomers, HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

solid

form

solid

form

solid

form

liquid

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−70°C

solubility

DMSO: 25 mg/mL, water: 50 mg/mL

solubility

DMSO: 25 mg/mL, water: 50 mg/mL

solubility

DMSO: 5 mg/mL

solubility

-

Skladovací třída

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Vyberte jednu z posledních verzí:

Osvědčení o analýze (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Dokumenty section.

Potřebujete-li pomoc, obraťte se na Zákaznická podpora

Již tento produkt vlastníte?

Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.

Navštívit knihovnu dokumentů

Questions

Reviews

No rating value

Active Filters