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810258E

Avanti

C11 TopFluor™ GM3

Avanti Research™ - A Croda Brand 810258E, ethanol solution

Synonyma:

C11 TopFluor GM3 Ganglioside (ammonium salt)

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About This Item

Empirický vzorec (Hillův zápis):
C65H110BF2N5O21
Číslo CAS:
2260795-48-8
Molekulová hmotnost:
1346.40
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

ethanol solution

packaging

pkg of 1 × 1 mL (810258E-100ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810258E

concentration

0.1 mg/mL (810258E-100ug)

shipped in

dry ice

storage temp.

−20°C

General description

C11 TopFluor™ GM3 is a fluorescent analog of ganglioside GM3 (Siaa2-3Galb1-4Glcb1-1Cer).

Application

C11 TopFluor™ GM3 has been used to visualize GM3 present in UGCG-KO1.3 cells by immunofluorescence microscopy.

Biochem/physiol Actions

Gangliosides function as modulators in regulating various receptor functions, involved in transmembrane signaling. GM3 plays an important role as a metabolic precursor for the formation of more complex gangliosides. It comprises between 80% and 90% of total ganglioside content in liver and adipose tissue, respectively. Additionally, GM3 is known to promote the subcellular redistribution of major caveolin enriched microdomain (CEM) components coordinating signal transduction. The increased levels of ganglioside GM3 in serum is reported in hyperlipidaemic, hyperglycaemic and type 2 diabetic patients.

Packaging

5 mL Amber Glass Screw Cap Vial (810258E-100ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

hcodes

H225,H319

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

55.4 °F - closed cup

flash_point_c

13.0 °C - closed cup

Osvědčení o analýze (COA)

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Navštívit knihovnu dokumentů

Seiichi Tagami et al.
The Journal of biological chemistry, 277(5), 3085-3092 (2001-11-15)
Gangliosides are known as modulators of transmembrane signaling by regulating various receptor functions. We have found that insulin resistance induced by tumor necrosis factor-alpha (TNF-alpha) in 3T3-L1 adipocytes was accompanied by increased GM3 ganglioside expression caused by elevating GM3 synthase
Christopher Lipina et al.
FEBS letters, 589(21), 3221-3227 (2015-10-06)
Gangliosides constitute a large family of sialic acid-containing glycosphingolipids which play a key regulatory role in a diverse array of cellular processes, including receptor-associated signalling. Accordingly, the aberrant production of the ganglioside GM3 has been linked to pathophysiological changes associated
Anshuman Das et al.
Nature microbiology, 5(9), 1069-1078 (2020-05-27)
The Picornaviridae are a diverse family of positive-strand RNA viruses that includes numerous human and veterinary pathogens1. Among these, hepatitis A virus (HAV), a common cause of acute hepatitis in humans, is unique in that it is hepatotropic and is
Jason G Kay et al.
Molecular biology of the cell, 23(11), 2198-2212 (2012-04-13)
Much has been learned about the role of exofacial phosphatidylserine (PS) in apoptosis and blood clotting using annexin V. However, because annexins are impermeant and unable to bind PS at low calcium concentration, they are unsuitable for intracellular use. Thus

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