936464

3-(3-Fluoro-4-piperidin-4-ylphenylamino)piperidine-2,6-dione hydrochloride

≥95%

• Synonyma: 2,6-Piperidinedione, 3-[[3-fluoro-4-(4-piperidinyl)phenyl]amino]-, hydrochloride
• Empirický vzorec (Hillův zápis): C₁₆H₂₀FN₃O₂ · xHCl
• Číslo CAS: 2654822-04-3
• Molekulová hmotnost: 305.35 (free base basis)
• UNSPSC Code: 12161600
• NACRES: NA.22

Vlastnosti

• Quality Segment: 100
• assay: ≥95%
• form: powder or crystals
• color: off-white to beige
• storage temp.: 2-8°C
• SMILES string: Cl.O=C1NC(=O)C(NC2=CC=C(C(F)=C2)C3CCNCC3)CC1
• InChI: 1S/C16H20FN3O2.ClH/c17-13-9-11(19-14-3-4-15(21)20-16(14)22)1-2-12(13)10-5-7-18-8-6-10;/h1-2,9-10,14,18-19H,3-8H2,(H,20,21,22);1H
• InChI key: VJQKECGXGMCYHY-UHFFFAOYSA-N

Popis

Application

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachment via reductive amination, and a basic building block for making protein degrader library.

Technology Spotlight:

targeted protein degradation
When used with other protein degrader building blocks
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable