934429

3-((4-(Piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride

≥95%

• Synonyma: 3-((4-(Piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride
• Empirický vzorec (Hillův zápis): C₁₆H₂₁N₃O₂ · xHCl
• Molekulová hmotnost: 287.36 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.21
• Assay: ≥95%
• Form: powder

Vlastnosti

• Quality Segment: 100
• assay: ≥95%
• form: powder
• storage temp.: 2-8°C
• SMILES string: O=C1NC(C(NC2=CC=C(C=C2)C3CCNCC3)CC1)=O.[xHCl]

Popis

Application

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

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Other Notes

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable