934240

Pomalidomide acetic acid

≥95.0%

• Synonyma: N-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]glycine
• Empirický vzorec (Hillův zápis): C₁₅H₁₃N₃O₆
• Číslo CAS: 927670-97-1
• Molekulová hmotnost: 331.28
• UNSPSC Code: 12352106
• NACRES: NA.21
• MDL number: MFCD31667076
• Assay: ≥95.0%
• Form: powder or crystals

Vlastnosti

• ligand: pomalidomide
• Quality Segment: 100
• assay: ≥95.0%
• form: powder or crystals
• storage temp.: 2-8°C

Popis

Application

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

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Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Legal Information

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Bezpečnostní informace

• Piktogramy: GHS08
• Výstražné slovo: Warning
• Kódy nebezpečí: H361d,H373
• Bezpečnostní pokyny: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2 - STOT RE 2
• Cílové orgány: Blood
• Skladovací třída: 11 - Combustible Solids
• Co se děje?: WGK 3
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable